Contraceptives of a new generation, or the Future without children


A new form of male contraceptive, called Vasalgel, is at arm’s length from testing on a man. However, people have heard such news more than once.

 

It’s time to look at several forms of male contraceptives that have not been put to general use because of a lack of funds.

RISUG (reversible control of sperm under control) and Vasalgel

What is it?

Vasalgel is a gel that is injected into the scrotum into the vas deferens, thereby blocking further movement of the sperm. However, this does not stop the movement of liquids, so a man who uses this gel will have ejaculation that does not contain spermatozoa. RISUG is a similar drug that does not block, but destroys spermatozoa. Either way, the gel acts for many years, and its action at any time can be stopped by one injection.

When did it first appear?

In India in 1979.

When was he last seen?

The manufacturer of RISUG in India plans to get permission to use it in the country this year. Vasalgel has proved its effectiveness this year in monkey trials in the US, and testing in humans can begin in 2018.

Why did the progress stop?

The Food and Drug Administration wants to see the RISUG test in the US before allowing further development. As for the research activities of Vasalgel, they are sponsored by non-profit organizations, since pharmaceutical companies are not interested in the drug. Still, in fact, unlike other contraceptives, this drug should be used only once. Non-profit companies are looking for investments and donations to continue research and tests.

Progestogen / testosterone

What is it?

This is an injection into the pelvic area of ​​two hormones, which must be done every two months. One, a form of testosterone, reduces male fertility. Another, progestogen, makes testosterone more effective, so you do not need to stab a large dose at once.

When did it first appear?

In the seventies, although for the first time it became known that testosterone had an effect on fertility, back in 1939.

When was he last seen?

In the framework of almost successful tests, the results of which were published in October 2016. Injections had 98% success in preventing pregnancy. However, five percent of men could not regain fertility, which is a big drawback.

Why did the progress stop?

These tests were completed prematurely due to side effects such as depression and mood jumps. The two clinics that participated in the trial were responsible for most of the cases with side effects, suggesting that something strange was happening there. The Ethics Council decided to discontinue the study. 75% of the men who participated in the trial reported that they were satisfied with the result they received, and would happily continue taking this drug.

Gossipol

What is it?

Gossypol is a chemical substance obtained from cotton seeds. Men who ate food cooked in cotton oil lost fertility, so scientists decided to find out whether gossypol can become an effective ingredient in men’s birth control pills.

When did it first appear?

In the seventies in China.

When was he last seen?

In the eighties in China, where scientists have tried to find a way to reduce the likelihood of chronic fatigue and even paralysis in men taking gossypol, and also determine whether they will be able to regain fertility.

Why did the progress stop?

The cause was side effects of the drug. 20% of the men who participated in the tests could not regain normal production of spermatozoa even two years after they stopped taking these pills. Also, this drug caused a dangerous shortage of potassium in the body, which led to the appearance of other terrible symptoms.

Clean Sheets (“Clean sheets” tablets)

What is it?

This is a drug that men can take before intercourse, which temporarily paralyze the muscles of the vas deferens, so that the movement of the sperm stops. The creators of the tablets say that the male orgasm will be felt the same way, but nothing will come out. Additional bonus: the probability of transmission of HIV and other sexually transmitted diseases decreases.

When did it first appear?

In the eighties on the basis of studying the results of animal studies conducted earlier.

When was he last seen?

In 2011, as part of a study on the blocking of sperm from sheep.

Why did the progress stop?

Again, the reason was the lack of finance. The same non-profit organizations that are currently promoting Vasalgel are working to draw attention to “Clean sheets”, but progress is much less rapid. So far, it has not even reached the point of declaring trials on humans, as happened with the gel mentioned above.

Why is it so difficult to create male contraceptives?

As with any drug that is planned to enter the market, the advantages should exceed the shortcomings and risks. Women already have risks in the form that they can become pregnant, so women’s contraceptives should be simply safer than bearing, giving birth and raising a child. A man does not have such a risk, so even the smallest actual risks can lead the drug out of the race.

Other forms of contraception

If there were no condoms and female contraception, then the need to develop male contraceptives would be more stringent. However, now there are too many active and safe means for women, so that male contraception is simply not relevant for medicine.

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